Comparing pharmaceutical persistence across terrestrial and aquatic environments: do studies according to OECD 307 and OECD 308 lead to similar outcomes?

Comparing pharmaceutical persistence across terrestrial and aquatic environments: do studies according to OECD 307 and OECD 308 lead to similar outcomes?

Blog Article

Abstract Information on transformation and persistence of chemical substances in the environment is important for hazard and risk assessment within a regulatory context or as a Picture Frames decision criterion in a safe and sustainable by design framework.Half-lives for human and veterinary medicinal products available from marketing authorization applications were compared between soil (OECD 307) and aquatic water/sediment systems (OECD 308).The comparison shows, that there is no obvious correlation between the Accent Table total system half-lives in the two different compartments and that surpassing persistence criteria is compartment-specific in 45% of the cases.